Education

2014 – 2019 Doctor of Philosophy, School of Pharmacy, National Taiwan University, Taipei, Taiwan
Research advisor: Dr. Pi-Hui Liang
*Synthesis of saponin-based vaccine adjuvant.
*Develop β-selective glycosylation methodology.

2009 – 2011 Master Degree of Chemistry, National Chiao Tung University, Hsinchu, Taiwan
Research advisor: Dr. Kwok-Kong Tony Mong
*Total synthesis study toward glycolipid derivatives of Meiothermus taiwanensis ATCC BAA-400.
*Stereoselective synthesis of galactosamine serine conjugates.

2005 – 2009 Bachelor Degree of Chemistry, National Chung Hsing University, Taichung, Taiwan

Professional Experiences

Sep 2022 – Present
National Defense Medical Center, Graduate Institute of Life Sciences
*Small-molecular drug conjugate
*Enzymatic synthesis

Jan 2020 – Dec 2020
Trainee, AstraZeneca, Gaithersburg, MD, USA
*Antibody drug conjugate synthesis, linker design, molecular modeling.

Jan 2019 – Dec 2019, Jan 2021 – July 2022
Post-doctoral fellow, National Taiwan University, Taipei, Taiwan
*Synthesis saponin-based vaccine adjuvant.
*Enzymatic synthesis.

Aug 2012 – Apr 2014
Deputy Researcher, Department of R&D, Formosa Lab., Inc. Tauyuan, Taiwan
*Manufacture of peptide antibiotics and small molecular drugs

Research Interests

Organic synthesis、Carbohyrate chemistry、Medicinal chemistry、
Enzymatic reaction、Structural analysis、 Molecular modeling

Recent Publications

1.C. K. Chang, P. F. Chiu, H. Y. Yang, Y. P. Juang, Y. H. Lai, T. S. Lin, L. C Hsu, Linda C. H. Yu, P. H. Liang, Targeting colorectal cancer with conjugates of a glucose transporter inhibitor and 5-fluorouracil. J. Med. Chem. 2021, 64, 4450-4461. (5 Apr. 2021)

2.P. H. Liang, Y. H. Lai, C. K. Chang, C. W. Chaw, Saponin conjugate and vaccine or pharmaceutical comprising the same. WO/2020/244483. (12 Oct 2020)

3.R. J. Liang,* Y. H. Lai,* Y. T. Kao, T. H. Yang, Y. L. Chen, H. J. Wang. A novel finding of nalbuphine-6-glucuronide, an active opiate metabolite, possessing potent antinociceptive effects: Synthesis and biological evaluation. Eur. J. Med. Chem. 2019, 178, 544-551. (11 Jun. 2019)

4.Y. J. Lu, Y. H. Lai,* Y. Y. Lin, Y. C. Wang, P. H. Liang. 2-O-N-Benzylcarbamoyl as a protecting group to promote beta-selective glycosylation and its applications in the stereoselective synthesis of oligosaccharides. J. Org. Chem. 2018, 83, 3688-3701. (7 Mar. 2018)

5.B. Ghosh, Y. H. Lai, Y. Y. Shih, T. K. Pradhan, C. H. Lin, K. K. Mong. Total synthesis of a glycoglycerolipid from Meiothermus taiwanensis through a one-pot glycosylation reaction and exploration of its immunological properties. Chem. Asian. J. 2013, 8, 3191-3199. (12 Sep. 2013)

6.S. R. Lu, Y. H. Lai, J. H. Chen, C. Y. Liu and K. K. Mong. Dimethylformamide: an unusual glycosylation modulator. Angew. Chem. Int. Ed. Engl. 2011, 50, 7315-7320. (17 Jun. 2011)