Experience

Visiting Scientist, National Heart & Lung Institute, Imperial College London (2017-2018)
Visiting Scientist, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (2013-2014)
Associate Professor, Department and Graduate Institute of Pharmacology, National Defense Medical Center (2017-present)
Assistant Professor, Department and Graduate Institute of Pharmacology, National Defense Medical Center (2013-2017)
Instructor, Department and Graduate Institute of Pharmacology, National Defense Medical Center (2010-2013)

Research Interests

Biomarkers and treatments of septic shock
Role of perivascular adipose tissue in vascular regulation
The mechanisms of platelet hyporeactivity in sepsis and heatstroke

Projects

Modulation of endothelium-dependent and endothelium-independent vasorelaxation pathways by perivascular adipose tissue in sepsis (108-2320-B-016-005-)
To explore the mechanisms of Juniperus communis extracts compound α-pinene suppress glioblastoma stem cell proliferation and invasion by regulating PLP2 (108-2320-B-016-007-)
Molecular mechanisms of resistance artery dysfunction caused by perivascular adipose tissue in sepsis (107-2320-B-016-013-)
Effects of perivacular adipose tissue on vascular tone regulation (continued II)(106-2320-B-016-002-)
The role of perivascular adipose tissue-derived relaxing factors (PVRFs) in sepsis-induced vascular dysfunction (106-2320-B-016-011-)

Publications

1.CC Shih, SJ Chen, A Chen, JY Wu, WJ Liaw, CC Wu (2008) Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. Critical Care Medicine, 36(6):1864-1872

2.JH Kuo, SJ Chen, CC Shih, WM Lue, CC Wu (2009) Abnormal activation of potassium channels in aortic smooth muscle of rats with peritonitis-induced septic shock. Shock, 32(1):74-79

3.SJ Chen, SY Li, CC Shih, MH Liao, CC Wu (2010) NO contributes to abnormal vascular calcium regulation and reactivity induced by peritonitis-associated septic shock in rats. Shock, 33(5):473-478

4.CC Shih, MF Tsai, SJ Chen, CM Tsao, SM Ka, HC Huang, CC Wu (2012) Effects of small volume hypertonic saline on acid-base and electrolytes balance in rats with peritonitis-induced sepsis. Shock, 38(6):649-655

5.CC Shih, PL Jiang, CM Tsao, ZF Chen, SJ Chen, CC Wu (2012) Vascular reactivity and membrane potential in survivors and non-survivors with peritonitis-induced septic shock. Journal of Medical Sciences, 33:75-83

6.MH Liao, CC Shih, CM Tsao, SJ Chen, CC Wu (2013) RhoA/Rho-kinase and nitric oxide in vascular reactivity in rats with endotoxaemia. PLoS One, 8: e56331

7.MH Liao, SJ Chen, CM Tsao, CC Shih*, CC Wu* (2013) Possible biomarkers of early mortality in peritonitis-induced sepsis rats. Journal of Surgical Research, 183:362-370

8.HP Hii, MH Liao, SJ Chen, CC Wu, CC Shih* (2015) Distinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock. PLoS One, 10(7): e0134492

9.CC Shih, HP Hii, CM Tsao, SJ Chen, SM Ka, MH Liao, CC Wu* (2016) Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats. PLoS One, 11(2): e0150319

10.CC Shih, LP Hsu, MH Liao, SS Yang, CY Wang, ST Ho, CC Wu (2016) Role of Sterile 20/SPS1-related Proline/Alanine-rich Kinase in Mice with Endotoxic Shock. Journal of Medical Sciences, 36:101-107

11.CC Shih*, MH Liao, TS Hsiao, HP Hii, CH Shen, SJ Chen, SM Ka, YL Chang, CC Wu (2016) Procainamide inhibits DNA methylation and alleviates multiple organ dysfuction in rats with endotoxic shock. PLoS One, 11(9): e0163690

12.CC Shih, LP Hsu, MH Liao, SS Yang, ST Ho, CC Wu (2017) Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice. European Journal of Pharmacology, 814:248-254

13.B Ahmetaj-Shala, M Olanipekun, A Tesfai, N MacCallum, N S Kirkby, GJ Quinlan, CC Shih, R Kawai, S Mumby, M Paul-Clark, EJ Want, JA Mitchell (2018) Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping. Scientific Reports, 8:13987

14.HJ Tsai, MH Liao, CC Shih, SM Ka, CM Tsao, CC Wu (2018) Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Critical Care, 22:269

15.CC Shih, PY Liu, JH Chen, MH Liao, CM Hsieh, SM Ka, CC Wu, HT Lin, TH Wu, YC Chen (2018) Macrophage expression of E3 ubiquitin ligase Grail protects mice from lipopolysaccharide-induced hyperinflammation and organ injury. PLOS ONE, 13 (12): e0208279