Professional Experiences

Executive member of a council of The Pharmacological Society in Taiwan (2020-present)
Executive Dean, Graduate Institute of Life Sciences, National Defense Medical Center (2014-present)
Chair, Systemic Biology Section, Graduate Institute of Life Sciences, National Defense Medical Center (2008-2012)
Chairman, Department and Institute of Pharmacology, National Defense Medical Center (2005-2011)
Visiting Professor, Department of Physiology, Medical College of Georgia, U.S.A. (2005-2006)
Visiting Professor, Department of Pharmacology and Pharmacy, University of Bath, U.K. (2002-2003)
Committeeman of Education Evaluation Committee, National Defense Medical Center (2001-2005)
Associate Editor of Journal of Medical Science, National Defense Medical Center (2001-2005; 2019-present)
Member of a council of The Pharmacological Society in Taiwan (2004-present)
General Secretary of The Pharmacological Society in Taiwan (2000-2004)
Professor, Department of Pharmacology, National Defense Medical Center (2000-present)
Visiting Associate Professor, Department of Physiology, University of Michigan, U.S.A. (1999-2000)
Associate Professor, Department of Pharmacology, National Defense Medical Center (1995-2000)
Post-doctor, The William Harvey Research Institute, St. Bartholomew's Hospital Medical College, University of London, U.K. (1995)
Senior Instructor, Department of Pharmacology, National Defense Medical Center (1990-1992)
Research Fellow, Department of Physiology, University of Michigan, U.S.A. (1989-1990)
Instructor, Department of Pharmacology, National Defense Medical Center (1987-1989)

Research Interests

Dr. Wu has been working on the cardiovascular diseases field since 1986. After he earned his Ph.D. degree, his research is more focusing on the pathogenesis and possible therapy of sepsis/septic shock. His ongoing researches are to investigate the effect of perivascular adipose tissue in the regulation of vascular tone and to examine old drugs new use in the sepsis animals. Recently, he extends his sepsis/septic shock research to heat stroke. He wishes to have breakthrough findings both in pathogenesis and therapy of sepsis/septic shock and heat stroke from the view of preventive medicine.

Research Activities & Accomplishments

Dr. Wu is the first to show that (1) selective inhibitors of inducible nitric oxide synthase have beneficial effects on animals with sepsis-induced multiple organ dysfunction, (2) abnormal activation of K+-channels contributes to vascular hyporeactivity to vasoconstrictors in septic shock, and (3) selective 2-agonists reduce mortality rate in animals with sepsis. Although he has been studying sepsis topic since 1991, he feels that the best treatment of sepsis is to keep your health as good as possible every day. Preventive medicine is the best therapy of sepsis.

Honors and Awards

Top Ten Distinguished Young Men in 2002 in Taiwan (elected by Taiwanese Young Businessmen Society) (2002)
Award for Excellent Military Medical Fellows/Teachers (Ministry of National Defense, Taiwan/R.O.C.) (1998, 2000, 2001, 2002)
Award for Excellent Scientific Article (elected by The Pharmacological Society in Taiwan, Taiwan/R.O.C.) (1997)
Award for Excellent Scientific Article (elected by Chinese Physiological Society, Taiwan/R.O.C.) (1991)
Award of Merit to Chin-Chen Wu for Research Achievement (Univ. of Michigan, U.S.A.) (1990)

Selected Publications

1. Tsai, H.J., C.C. Shih, K.Y. Chang, M.H. Liao, W.J. Liaw, C.C. Wu, C.M. Tsao: Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Sci. Report 11:610, 2021.

2. Huang, H.C., T.S. Hsiao, M.H. Liao, C.M. Tsao, C.C. Shih, C.C. Wu*: Low-dose hydralazine improves endotoxin-induced coagulopathy and multiple organ dysfunction via its anti-inflammatory and anti-oxidative/nitrosative properties. Eur. J. Pharmacol. 882:173279, 2020.

3. Tsai, H.J., M.H. Liao, C.C. Shih, S.M. Ka, C.M. Tsao, C.C. Wu. Angiotensin-(1-7) attenuates organ injury and mortality in rats with polymicrobial sepsis. Critical Care 22:269, 2018.

4. Shih, C.C., L.P. Hsu, M.H. Liao, S.S. Yang, S.T. Ho, C.C. Wu*: Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice. Eur. J. Pharmacol. 814:248-254, 2017.

5. Shih, C.C., H.P. Hii, C.H. Shen, M.H. Liao, S.J. Chen, S.M. Ka, C.C. Wu*: Procainamide inhibits DNA methylation and alleviates multiple organ dysfunction in rats with enodotoxic shock. PLoS One 11(9): e0163690, 2016.

6. Tsai, H.J., C. Ding, C.M. Tsao, M.H. Liao, S.M. Ka, W.J. Liaw, C.C. Wu*: Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia - A potential application of thrombelastography in endotoxin-induced sepsis. Blood Coagul. Fibrin. 26:175-184, 2015.

7. Tsao, C.M., K.Y. Li, S.J. Chen, S.M. Ka, W.J. Liaw, H.C. Huang, C.C. Wu*: Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model. Critical Care, 18:652, 2014.

8. Lee, M.H.H., S.J. Chen, C.M. Tsao, C.C. Wu*: Perivascular adipose tissue inhibits endothelial function of rat aortas via caveolin-1. PLoS ONE 9(6):e99947, 2014.

9. Liao, M.H., C.C. Shih, C.M. Tsao, S.J. Chen, C.C. Wu*: RhoA/Rho-kinase and nitric oxide in vascular hyporeactivity in rats with endotoxaemia. PLoS ONE 8:e56331, 2013.

10. Liu, H.W., M.C. Liu, C.M. Tsao, M.H. Liao, C.C. Wu*: Electro-acupuncture at “Neiguan (PC6)” acupoint attenuates liver injury in endotoxaemic rats. Acupunct. Med. 29:284-288, 2011.

11. Tsao, C.M., S.J. Chen, M.C. Shih, W.M. Lue, M.Y. Tsou, A. Chen, W.J. Liaw, C.C. Wu: Effects of terbutaline on circulatory failure and organ dysfunction induced by peritonitis in rats. Intens. Care Med. 36:1571–1578, 2010.

12. Shih, C.C., S.J. Chen, A. Chen, J.Y. Wu, W.J. Liaw, C.C. Wu*: Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. Crit. Care Med. 36:1864-1872, 2008.

13. Wu, J.Y., M.Y. Tsou, T.H. Chen, S.J.Chen, C.M. Tsao, C.C. Wu*: Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. J. Pineal Res. 45:106-116, 2008.

14. Tsao, C.M., S.T. Ho, W.J. Liaw, A. Chen, C.C. Wu*: Combined effects of propofol and dexamethasone on rats with endotoxemia. Crit. Care Med. 36: 887-894, 2008.

15. Wu, C.C.*: Possible therapies of septic shock: Based on animal studies and clinical trials. Curr. Pharm. Des. 12:3535-3541, 2006.

16. Liaw, W.J., T.H. Chen, Z.Z. Lai, S.J. Chen, A. Chen, C. Tzao, J.Y. Wu, C.C. Wu*: Effects of a membrane-permeable radical scavenger, tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock 23:88-97, 2005.

17. Wu, C.C.*: Nitric oxide in inflammation. Curr. Med. Chem. (Anti-inflammatory Anti-allergy agents) 3:217-222, 2004.

18. Wu, C.C.*, S.J. Chen and C.J. Garland: NO and KATP-channels underlie endotoxin-induced smooth muscle hyperpolarization in rat mesenteric resistance arteries. Br. J. Pharmacol. 142:479-484, 2004.

19. Chen, S.J., C.C. Wu*, S.N. Yang, C.I. Lin and M.H. Yen: Hyperpolarization contributes to vascular hyporeactivity in rats with endotoxic shock. Life Sci. 68:659-668, 2000.

20. Chen, S.J., C.C. Wu*, S.N. Yang, C.I. Lin and M.H. Yen: Abnormal activation of K+ channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence. Br. J. Pharmacol. 131:213-222, 2000.

21. Wu, C.C.*, S.J. Chen and M.H. Yen: Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats. Am. J. Physiol. 275:H1148-H1157, 1998.