Research Interest
1.Obesity and metabolic disease
2.Brown and beige adipogenesis
3.Postmenopausal pathogenesis and cardiovascular disease
Publication List
1. Shen HH, Yang CY, Kung CW, Chen SY, Wu HM, Cheng PY, Lam KK, Lee YM*. Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3T3-L1 cells. Journal of Biomedical Science 2019 (accepted)
2. Shen HH, Huang SY, Kung CW, Chen SY, Chen YF, Cheng PY, Lam KK, Lee YM. Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high fat diet. Journal of Nutritional Biochemistry. 2019;67: 111–122
3. Shen HH, Huang SY, Cheng PY, Chu YJ, Chen SY, Lam KK, Lee YM. Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats. Menopause. 2017;24(8); 959-969
4. Shen HH, Liao MH, Chang YH, Lee YM. Estrogen deficiency modifies matrix metalloproteinases activity and vascular function of mesenteric arteries in female rats. J Med Sci 2017;37(2):41-48.
5. Chung MT, Lee YM, Shen HH, Cheng PY, Huang YC, Lin YJ, Huang YY, Lam KK. Activation of autophagy is involved in the protective effect of 17β-estradiol on endotoxemia-induced multiple organ dysfunction in ovariectomized rats. J Cell Mol Med. 2017 Dec;21(12):3705-3717.
6. Wang YL, Shen HH, Cheng PY, Chu YJ, Hwang HR, Lam KK, Lee YM.17-DMAG, An HSP90 inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats. PLoS One. 2016; 11(5):e0155583.
7. Shen HH, Lam KK, Cheng PY, Kung CW, Chen SY, Lin PC, Chung MT, Lee YM. Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats. Shock. 2015; 43(4):405-411.
8. KK Lam, PY Cheng, GH, SY Chen, Shen HH, MH Yen and YM Lee: Estrogen Deficiency-Induced Alterations of Vascular MMP-2, MT1-MMP, and TIMP-2 in Ovariectomized Rats. Am J Hypertens. 2009 Jan;22(1):27-34.
Symposium Poster
1 .Role of heat shock proteins in the protective effect of raloxifene in endotoxemic rats
Shen HH, Chu YJ, YM Lee
Pacifichem 2015: The International Chemical Congress of Pacific Basin Societies 2015, Honolulu, USA
2. Combination of α-lipoic acid and genistein induces white adipose tissue browning through modulation of autophagy in ovariectomized rats
Tsai PF, Lee YM, Shen HH
The 34th Joint Annual Conference of Biomedical Science, Taipei