Specialty

Cardiovascular Pharmacology

Professional Carrier

2015/08-Present Professor, Department of Pharmacology, National Defense Medical Center
2011/08-2014/08 Chairman of Department of Pharmacology, National Defense Medical Center
2006/08-2015/07 Associate Professor, Department of Pharmacology, National Defense Medical Center
2001/08-2006/07 Assistant Professor, Department of Pharmacology, National Defense Medical Center
- Teaching Instructor, Department of Pharmacology, National Defense Medical Center (1998/08-2001/07)
- Teaching Assistant, Department of Pharmacology, National Defense Medical Center (1993/09-1998/07)

Research interests

Postmenopausal cardiovascular diseases and metabolic syndrome;
Sepsis;
Heat stroke;
Myocardial ischemia/reperfusion injury

Selected Publication

*: corresponding author; #: equal contribution
1.Yi-Li Wang, Kwok-Keung Lam, Pao-Yun Cheng, Yen-Mei Lee*. Celastrol prevents circulatory failure via induction of haem oxygenase-1 and heat shock protein 70 in endotoxemic rats. Journal of Ethnopharmacology 2015 Mar 13, 162:168-175; SCI, IF: 3.414, Ranking: 14.81 % (Integrative & complementary medicine 4/27).

2.Hsin-Hsueh Shen, Kwok-Keung Lam, Pao-Yun Cheng, Ching-Wen Kung, Shu-Ying Chen, Pei-Chiang Lin, Ming-Ting Chung*, Yen-Mei Lee*. Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats. Shock 2015 Apr; 43(4):405-411. SCI, IF: 3.083, Ranking: 21.18 % (Surgery 43/203).

3.Yung-Chieh Tsai, Yen-Mei Lee, Chih-Hsiung Hsu, Sy-Ying Leu, Hsiao-Yen Chiang, Mao-Hsiung Yen, Pao-Yun Cheng*. The effect of ferulic acid ethyl ester on leptin-induced proliferation and migration of aortic smooth muscle cells. Experimental & Molecular Medicine 2015 Aug 28; 47, e180; doi:10.1038/emm.2015.56. SCI, IF: 4.743, Ranking: 17.78 % (Biochemistry & Molecular Biology 53/298).

4.Yi-Li Wang, Hsin-Hsueh Shen, Pao-Yun Cheng, Yen-Ju Chu, Hwong-Ru Hwang, Kwok-Keung Lam*, Yen-Mei Lee*. 17-DMAG, An HSP90 inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats. PLoS One 2016 May 25;11(5):e0155583; SCI, IF: 2.776, Ranking: 34.78 % (Multidisciplinary sciences 24/69).

5.Yung-Chieh Tsai, Kwok-Keung Lam, Yi-Jen Peng, Yen-Mei Lee, Chung-Yu Yang, Yi-Ju Tsai, Mao-Hsiung Yen, Pao-Yun Cheng*. Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke. Journal of Cellular and Molecular Medicine 2016 Oct;20(10):1889-97. doi: 10.1111/jcmm.12881, SCI, IF: 4.658, Ranking: 22.79 % (Medicine, Research and Experimental 31/136).

6.Yung-Chieh Tsai, Sy Ying Leu, Yi-Jen Peng, Yen-Mei Lee, Chih-Hsiung Hsu, Shen-Chieh Chou, Mao-Hsiung Yen, Pao-Yun Cheng*. Genistein suppresses leptin-induced proliferation and migration of vascular smooth muscle cells and neointima formation. Journal of Cellular and Molecular Medicine 2017 Mar;21(3):422-431. doi: 10.1111/jcmm.12986, SCI, IF: 4.658, Ranking: 22.79 % (Medicine, Research and Experimental 31/136).

7.Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam*, Yen-Mei Lee*. Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats. Menopause 2017 Aug;24(8):959-969, SCI, IF: 2.942, Ranking: 14.46 % (Obstetrics & Gynecology 12/83).

8.Ming-Tzeung Chung#, Yen-Mei Lee#, Hsin-Hsueh Shen, Pao-Yun Cheng, Yu-Chen Huang, Yu-Ju Lin, Yu-Yang Huang, Kwok-Keung Lam*. Activation of autophagy is involved in the protective effect of 17-oestradiol on endotoxaemia-induced multiple organ dysfunction in ovariectomized rats. Journal of Cellular and Molecular Medicine 2017 Dec; 21(12):3705-3717. SCI, IF: 4.658, Ranking: 22.79 % (Medicine, Research and Experimental 31/136).

9. Hsin-Hsueh Shen, Shieh-Yang Huang, Ching-Wen Kung, Shu-Ying Chen, Ya-Fen Chen, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee*. Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high fat diet. Journal of Nutritional Biochemistry 2019 Feb; 67:111-122. SCI, IF: 4.49, Ranking: 15.12 % (Nutrition & Dietetics 13/86).

10.Hsin-Hsueh Shen, Chien-Yi Yang, Ching-Wen Kung, Shu-Ying Chen, Hong-Min Wu, Pao-Yun Cheng, Kwok-Keung Lam, Yen-Mei Lee*. Raloxifene inhibits adipose tissue inflammation and adipogenesis through Wnt regulation in ovariectomized rats and 3T3-L1 cells. Journal of Biomedical Science 2019, accepted, SCI, IF: 5.203, Ranking: 14.3 % (Medicine, Research & Experimental 20/136)