Position

Professor and Director

Education

Bachelor in Medicine School of Medicine, National Defense Medical Center, R.O.C., 1989

Ph.D. Department of Cell Biology, Yale University, U.S.A., 1997

E-MAIL

shyujeff@ndmctsgh.edu.tw

Research Interests

1. Study of cell and molecular mechanism of bone remodeling.

2. Study of antiresorptives and bone anabolics for treatment of postmenopausal osteoporosis

3. Human umbilical mesenchymal stem cells and regeneration medicine for diabetes and osteoporosis.

4. Study of brain disorder induced by autoimmune and endocrine dysfunction.

Professional Experiences

1989-1992 Teaching Assistant, Department of Biology and Anatomy, National Defense Medical Center, R.O.C.

1993-1994 Teaching Assistant, Department of Cell Biology, Yale University, U.S.A.

1997-2007 Assistant Professor, Department of Biology and Anatomy, National Defense Medical Center, R.O.C.

2007-2013 Associate Professor, Department of Biology and Anatomy, National Defense Medical Center, R.O.C.

2013-present Professor, Department of Biology and Anatomy, National Defense Medical Center, R.O.C.



2000-2003 Resident Doctor, Department of Psychiatry, Tri-Service General Hospital, R.O.C.

2004-2005 Chief Resident Doctor, Department of Psychiatry, Tri-Service General Hospital, R.O.C.

2005-present Visiting Doctor, Department of Psychiatry, Tri-Service General Hospital, R.O.C.

Publications

1. Gunng-Shinng Chen, Jia-Fwu Shyu, Yung-Bor Lin, Teen-Meei Wang, and Jiang-Chuan Liu. The effects of surgical denervation of inferior alveolar nerve and superior cervical ganglion on dentin formation in the rat. Journal of Medical Science. 1990. 10:349-354.

2. Teen-Meei Wang, Jia-Fwu Shyu, Webster. S.S. Jee, and James L. Matthews. Evidence for reduced cancellous bone mass in the spontaneously hypertensive rat. Bone & Mineral. 1993. 20:251-64

3. William C. Horne, Jia-Fwu Shyu, Munmun Chakraboty and Roland Baron. Signal transduction by calcitonin: Multiple ligands, receptors and signaling pathways. Trends in Endocrinology and Metabolism. 1994. 5:395-401.

4. Jia-Fwu Shyu, Daisuke Inoue, Roland Baron and William C Horne. The deletion of fourteen amino acids in the seventh transmembrane domain of a natural occurring calcitonin receptor isoform alters ligand binding and selectively abolished coupling to phospholipase C. Journal of Biological Chemistry. 1996. 271:31127-31134.

5. Jia-Fwu Shyu. The cloning and characterization of the C1a and CTRΔe13 isoforms of the rabbit osteoclast calcitonin receptor. Ph.D. Thesis. 1997.

6. Yan Chen, Jia-Fwu Shyu, Anu Santhanagopal, Daisuke Inoue, Jean-Pierre David, Jeffery Dixon, Willam C. Horne and Roand Baron. The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation: involvement of Gi, protein kinase C and calcium. Journal of Biological Chemistry. 1998. 273:19809-19816.

7. Jia-Fwu Shyu, Zhiyuan Zhang, Laura Hernandez-Lagunas, Claudia Camerino, Yan Chen, Daisuke Inoue, Roland Baron, and William C. Horne. Protein kinase C antagonizes pertussis toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. European Journal of Biochemistry. 1999. 262:95-101.

8. Tien-Hua Chen, Chien-Hsing Chen, Jia-Fwu Shyu, Chew-Wun Wu, Wing-Yui Lui, and Jiang-Chuan Liu. Distribution of superficial temporal artery in the Chinese adult. Plastic and Reconstructive Surgery. 1999. 104:1276-1279.

9. Ta-Lee Chang, Tien-Hua Chen, Rong-Hwan fang, Jia-Fwu Shyu, Hung-Chun Chung, Wing-Yui Lui, Jiang-Chuan Liu. Distribution of the superficial veins in cubital fossa in Chinese adults. Journal of Plastic and Reconstruction Surgery. R.O.C. 1999. 8: 167-172.

10. Tien-Hua Chen, Jia-Fwu Shyu, Chien-Hsing Chen , Kuo-Hsing Ma, Chew-Wun Wu, Wing-Yui Lui, and Jiang-Chuan Liu. Variations of the cystic artery in Chinese adults. Surgical Laparoscopy Endoscopy & Percutaneous Techniques. 2000. 10:154-157.

11. Zan-Chung Zaung, Tien-Hua Chen, Jia-Fwu Shyu, Wing-Yiu Lui and Jiang-Chuan Liu. The relationship between the palmaris longus tendon and the palmar cutaneous branch of the median nerve. Journal of Plastic and Reconstruction Surgery. R.O.C. 2001. 10: 1-6.

12. Wan-Cherng Liu, Tien-Hua Chen, Jia-Fwu Shyu, Chien-Hsing Chen, Chung Shih, Jaang J. Wang, Sung-Pao Kung, Wing-Yui Lui, Chew-Wun Wu, and Jiang-Chuan Liu. Applied anatomy of the genital branch of genitofemoral nerve in open inguinal herniorraphy. European J. Surgery. 2002. 168:145-149.

13. Juh-Wen Cheung, Jia-Fwu Shyu, Chih-Chuan Teng, Tien-Hua Chen, Cheng-His Su, Yi-Ming Shyr., Wang, J.J., Chew-Wen Wu, Lui, W.Y., Jiang-Chuan Liu. The anatomical variations of the palmar cutaneous branch of the median nerve in Chinese adults. Journal of the Chinese Medical Association: JCMA. 2004. 67:27-31.

14. Kuo-Ying Liu, Jia-Fwu Shyu, Yih-Huei Uen, Tien-Hua Chen, Yi-Ming Shyr, Cheng-His Su, Chew-Wun Wu, Wing-Yiu Lui. Acute appendictis in patients with acquired immunodeficency syndrome. Journal of the Chinese Medical Association: JCMA. 2005. 68:226-229.

15. Antineural antibody in patients with Tourette’s syndrome and their family members. Chin-Bin Yeh, Ching-Hsing Wu, Hui-Chu Tsung, Chia-Wei Chen, Jia-Fwu Shyu*, James F. Leckman. Journal of Biomedical Sciences. 2006. 13:101-112.

16. Yih-Huei Uen, Tien-Hua Chen, Jia-Fwu Shyu*, Yi-Ming Shyr, Cheng-Hsi Su, Jui-Yu Chen, Chen-Shen Lee, and Jiang-Chuan Liu. Surgical anatomy of the recurrent laryngeal nerve in Chinese adults and its clinical applications. Surgery Today. 2006. 36:312-315.

17. Jia-Fwu Shyu, Tien-Hua Chen, Yi-Ming Shyr, Cheng-Hsi Su, Chew-Wun Wu, Wing-Yiu Lui. Gastric body partition to avoid ulcergenic risk and hypergastrinemia. Surgery. 2006. 140:44-49.

18. Jia-Fwu Shyu, Tien-Hua Chen, Yi-Ming Shyr, Cheng-His Su, Chew-Wen Wu, Wing-Yiu Lui. Gastric body partition for giant perforated peptic ulcer in critically ill elderly patients. World J. of Surgery. 2006. 30:2204-2207.

19. Yi-Fang Tsai, Jia-Fwu Shyu, Tien-Hua Chen, Yi-Ming Shyr, Cheng-Hsi Su. Effect of preoperative biliary drainage on surgical outcome after pancreaticoduodenectomy. Hepato-Gastroenterology. 2006. 53:823-827.

20. Jia-Fwu Shyu*, Chung Shih, Chiung-Ying Tseng, Chi-Hung Lin, Der-Tzong Sun, Hsiao-Tung Liu, Hui-Chu Tsung, Tien-Hua Chen, Ru-Band Lu. Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities. Bone. 2007. 40:1329-1342.

21. Jui-Yu Chen, Jia-Fwu Shyu, Yih-Huei Uen, Wen-Chuan Hsiao, Cheng-Hsi Su ,Yi-Ming Shyr, Chew-Wun Wu , Wing-Yui Lui, Jiang-Chuan Liu, Tien-Hua Chen. Surgical anatomy of the gastroduodenal artery in Chinese adults and its clinical applications. Hepato-Gastroenterology. 2007. 54:1458-1461.


22. Chou PH, Shyu JF, Ma HL, Wang ST, Chen TH. Courses of the radial nerve differ between Chinese and Caucasians. Clinical Orthopaedics and Related Research. 2008 Jan; 466:135-138. (IF=2.533, 12/65 in Orthopedics)





23. Hsieh PS, J. Chan YH, Shyu JF, Chen YT, Loh CH. Mild portal endotoxaemia induces subacute hepatic inflammation and pancreatic b-cell dysfunction in rats. European Journal of Clinical Investigation. 2008 Sep; 38:640-648. (IF=3.018, 21/155 in Medicine, General & Internal)

24. Hsieh PS, Tsai HC, Kuo CH, J. Chan TH, Shyu JF, Cheng WT, and Liu TT. Selective COX2 inhition improves whole body and muscular insulin resistance in fructose-fed rats. European Journal of Clinical Investigation. 2008 Nov; 38:812-819. (IF=3.018, 21/155 in Medicine, General & Internal)

25. Chao CY, Gau SF, Mao WC, Shyu JF, Chen YC, Yeh CB. Relationship of attention-deficit-hyperactivity disorder symptoms, depressive/anxiety symptoms, and life quality in young men. Psychiatry and Clinical Neurosciences. 2008 May; 62:421-427. (IF=2.133, 71/130 in Psychiatry)

26. Chuang FJ, Chen JY, Shyu JF, Su CH, Shyr YM, Wu CW, Lui WY, Lee CS, Chen TH. Surgical anatomy of the external branch of the superior laryngeal nerve in Chinese adults and its clinical applications. Head and Neck. 2010 Jan; 32:53-57. (IF=2.403, 5/41 in Otorhinolaryngology)

27. Wang HS, Shyu JF, Shen WS, Hsu HC, Chi TC, Chen CP, Huang SW, Shyr YM, Tang KT, Chen TH. Transplantation of insulin producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice. Cell Transplantation. 2011 March; 20:455-466. (IF=6.204, 1/25 in Transplantation)

28. Shyu JF, Wang HS, Shyr YM, Wang SE, Chen CH, Tan JS, Lin MF, Chen TH. Alleviation of hyperglycemia in diabetic rats by intraportal injection of insulin-producing cells generated from surgically resected human pancreatic tissue. Journal of Endocrinology. 2011 Mar; 208:233-244. (IF=3.548, 39/122 in Endocrinology and Metabolism)

29. Liu KY, Chen TH, Shyu JF, Wang ST, Liu JY, Chou PH. Anatomic study of the axillary nerve in a Chinese cadaveric population: correlation of the course of the nerve with proximal humeral fixation with intramedullary nail or external skeletal fixation. Archives of Orthopaedic and Trauma Surgery. 2011 May; 131:669-674. (IF=1.369, 30/65 in Orthopedics)

30. Tsai PJ, Wang HS, Huang SW, Shyr YM, Shyu JF*, Chen TH. Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. Journal of Biomedical Science. 2012 April; 19:47. (IF=1.980, 63/112 in Medicine, Research & Experimental)

31. Kuo YJ, Tsuang FY, Sun JS, Lin CH, Chen CH, Li JY, Huang YC, Chen WY, Yeh CB, Shyu JF*. Calcitonin Inhibits SDCP-induced Osteoclast Apoptosis and Increases its Efficacy in a Rat Model of Osteoporosis. PLoS ONE. 2012 Jul; 7:e40272. (IF=4.092, 12/84 in Biology)

32. Yeh CB, MD, Shui HA, Chu TH, Chen YA, MS; Tsung HC, Shyu JF*. Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette’s Syndrome autoimmunity. Journal of Neuroimmunology. 2012 Sep. 250:18-26. (IF=2.959, 114/243 in Neurosciences)

33. Yeh CB, Huang WS, Chang CJ, Ma KH, Shyu JF*. The rCBF brain mapping in adolescent ADHD comorbid developmental coordination disorder and its changes after MPH challenging. European J Paediatric Neurology. 2012 Nov.; 16:613-618. (IF=2.123, 33/115 in Pediatric)

34. Yeh CB, Shyu JF, Hung CH, Wan FJ. The level of nitric oxide and peak expiration flow rate in individuals with Tourette’s syndrome and their family members. J Medical Sciences. 2012 Dec. 32(6):279-285.

35. Huang SP, Huang CH, Shyu JF, Lee HS, Chen SG, Chan YH James, Huang SM. Promotion of wound healing using adipose-derived stem cells in radiation ulcer of a rat model. Journal of Biomedical Science. 2013 July; 20:51. (IF=2.458, 57/121 in Medicine, Research & Experimental)

36. Tsai PJ, Wang HS, Lin CH, Weng ZC, Chen TH, Shyu JF*. Intraportal Injection of Insulin-Producing Cells Generated from Human Bone Marrow Mesenchymal Stem Cells Decreases Blood Glucose Level in Diabetic Rats. Endocrine Research. 2014 Jan. 39(1):26-33. (IF=1.026, 106/122 in Endocrinology and Metabolism)

37. Chang CC, Ku CH, Hsu WC, Hu YA, Shyu JF, Chang ST. Five-day, low-level laser therapy for sports-related lower extremity periostitis in adult men: a randomized, controlled trial. Lasers Med Sci. 2014 May. 29:1485-1494. (IF=2.402, 45/199 in Surgery)

38. Tseng FJ, Chia WT, Shyu JF, Gou GH, Sytwu HK, Hsia CW, Tseng MJ, Pan RY. Interactomics profiling of the negative regulatory function of carbon monoxide on RANKL-treated RAW 264.7 cells during osteoclastogenesis. BMC Syst Biol. 2014 May. 8(1):57. (IF=2.982, 7/47 in Mathematical and Computational Biology)

39. Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF*. Undifferentiated Wharton’s jelly mesenchymal stem cells transplantation induces insulin-producing cell differentiation and suppression of T cell-mediated autoimmunity in non-obese diabetic mice. Cell Transplantation. 2014 July. (Accepted, IF=3.570, 5/26 in Transplantation)

40. Lin CY, Zu CH, Yang CC, Tsai PJ, Shyu JF, Chen CP, Weng ZC, Chen TH, Wang HS. IL-1β-induced mesenchymal stem cell migration involves MLCK activation via PKC signaling. Cell Transplantation. 2014 Oct. (Accepted, IF=3.570, 5/26 in Transplantation)

41. Yeh CB, Chang KW, Chan James YH, Huang SM, Chu TH , Wei NK, Ma HS , Cheng JZ, Ma KH, Chen TH, Shyu JF*. Calcitonin alleviates hyperalgesia in ovariectomized-induced osteoporotic rats by modulating brain serotonin transporter activity. 2015. (In preparation) *Corresponding author

Conferences papers:

1. Cloning and characterization of the rabbit osteoclast calcitonin receptor. 1994. Jia-Fwu Shyu, William C Horne and Roland Baron. Journal of Bone and Mineral Research 9(suppl):s307.

2. Rabbit osteoclasts express two isoforms of the calcitonin receptor, one of which is novel. 1995. Jia-Fwu Shyu, Roland Baron and William C Horne. Journal of Bone and Mineral Research 10(suppl):s486.

3. The isoform of the rabbit calcitonin receptor that lacks of 14 amino acids in the 7th transmembrane domain has altered ligand binding and receptor coupling properties. 1996. Jia-Fwu Shyu, Daisuke Inoue, Roland Baron and William C Horne. Journal of Bone and Mineral Research 11(suppl):s203.

4. The calcitonin receptor activates Gi-dependent signal transduction in a cell-specific manner. Modulation of Gi coupling by PKC. 1997. Jia-Fwu Shyu, Yan Chen, Daisuke Inoue, Claudia Camerino, Roland Baron and William C Horne. Journal of Bone and Mineral Research 12(suppl):s322.

5. Calcitonin-induced phosphorylation of an N-terminal epitope-tagged calcitonin receptor expressed in HEK-293 cells. 1998. Jia-Fwu Shyu, Chung Shih, William C Horne and Roland Baron. Journal of Bone and Mineral Research 13(suppl):s322.

6. Calcitonin induces detachment of isolated rabbit osteoclasts by modulating PYK2 activity. 1999. Jia-Fwu Shyu, Chiung-Ying Tseng, Yu-Wen Wang, Chi-Hung Lin. Molecular Biology of the Cell 10(suppl):53a.

7. PYK2 mediates calcitonin-induced detachment of osteoclasts by modulating protein kinase C, phosphatase activities, and intracellular calcium concentration. 2000. Jia-Fwu Shyu, Chung Shih, Chi-Hung Lin, Yu-Wen Wang, Chiung-Ying Tseng. Journal of Bone and Mineral Research 15(suppl):s251.

8. Estrogen modulates RANK expression and RANK-mediated signaling in the rabbit osteoclast. 2001. Jia-Fwu Shyu, Yu-Ying Lin, Jaang J. Wang, Chi-Hung Lin, Chung Shih. Journal of Bone and Mineral Research 16(suppl):s509.

9. PYK2-mediated signaling is involved in calcitonin-induced sealing zone detachment in resorbing osteoclasts. 2002. Jia-Fwu Shyu, Chung Shih, J.J. Wang, Chi-Hung Lin. Journal of Bone and Mineral Research 17(supp1 l):s252.

10. Evaluation of diagnostic and prognostic values of anti-neuronal antibodies in patients with Tourette’s syndrome. 2003. Jia-Fwu Shyu, Chin-Bin Yeh (葉啟斌), Chia-Wei Chen, Hui-Chu Tsung (鍾惠菊), and Ching-Hsing Wu. Taiwanese Society of Psychiatry, annual meeting. 54-55.

11. Evidence for involvement of PYK2-mediated signaling in calcitonin-induced sealing zone detachment in osteoclasts microinjected with fluorescent G-actin. 2004. Jia-Fwu Shyu, Chi-Hung Lin, Hong-Shing Chen (陳宏興), Hui-Chu Tsung (鍾惠菊), Chung Shih. Journal of Bone and Mineral Research 19(supp1 l):s418.

12. The family study of anti-neuronal antibodies in the cases of Tourette’s syndrome. 2004. Jia-Fwu Shyu, Chin-Bin Yeh, Chia-Wei Chen (陳嘉偉), Hui-Chu Tsung (鍾惠菊), Xiao- Wei Ho (侯孝偉), and Ching-Hsing Wu. Taiwanese Society of Psychiatry, annual meeting abstract, 316.

13. The immunological profile in the normal healthy adults with involuntary movement induced by antipsychotic. 2004. Jia-Fwu Shyu, Chin-Bin Yeh (葉啟斌), Chun-Lung Lin, Hui-Chu Tsung (鍾惠菊), Xiao- Wei Ho (侯孝偉), Chih-Wei Wang, Yuan-Hwa Chou. Taiwanese Society of Psychiatry, annual meeting abstract, 318.

14. The role of Pyk2/Src in calcitonin-induced podosome reassembly and sealing zone detachment in osteoclasts. 2005. Jia-Fwu Shyu, Chung Shih, Wen-Zhi Lin (林文智), Hsiao-Tung Liu (劉效同). Journal of Bone and Mineral Research 20(supp1 l):s375.

15. Proteomic analysis of the specific antigen recognized by anti-neuronal antibodies from sera of patients with Tourette syndrome. 2005. Jia-Fwu Shyu, Chin-Bin Yeh (葉啟斌), Hui-Chu Tsung (鍾惠菊), Chih-Wei Wang, Xiao- Wei Ho (侯孝偉), Ching-Hsing Wu. Taiwanese Society of Psychiatry, annual meeting abstract, 284.

16. The role of protein tyrosine phosphatases in the calcitonin induced detachment effect in osteoclasts. 2006. Jia-Fwu Shyu, Hsiao-Tung Liu (劉效同), Chun-Chao Hsu (許君兆), Chung. Shih. Journal of Bone and Mineral Research 21(supp1 l):s262.

17. A study of the role of HCN-4 in the pathogenesis of Tourette’s syndrome. Jia-Fwu Shyu, Chin-Bin Yeh (葉啟斌), Tzu-Hui Chu, Hui-Chu Tsung (鍾惠菊), Chih-Wei Wang, Yu-An Chen (陳佑安). 2006. Taiwanese Society of Psychiatry, annual meeting abstract, 267.

18. A study of the role of HCN-4 in the pathogenesis of Tourette’s syndrome. Jia-Fwu Shyu, Chin-Bin Yeh (葉啟斌), Tzu-Hui Chu, Hui-Chu Tsung (鍾惠菊), Chih-Wei Wang, Yu-An Chen. 2007. Taiwanese Society of Psychiatry, annual meeting abstract, 358.

19. The antineural antibody in the sera of patients with Tourette's syndrome. Chin-Bin Yeh (葉啟斌), Jia-Fwu Shyu, Tzu-Hui Chu, Yu-An Chen (陳佑安), Hui-Chu Tsung (鍾惠菊). 2008. Taiwanese Society of Psychiatry, annual meeting abstract, 55.

20. Functional neoislet generation from adult human pancreatic tissue with soft parenchyma. Shin-E Wang, Jia-Fwu Shyu, Yi-Ming Shyr, Hwai-Shi Wang, Hui-Chu Tsung (鍾惠菊), Chia-Hsiang Chen, Po-Shiuan Hsieh, Huey-Kang Sytwn, Tien-Hua Chen. 2008. International Symposia on Stem Cells, Epigenetics and Development. Abstracts 104.

21. Characterization of decoy receptor 3-transduced neoislets differentiated from adult human pancreas endocrine precursor cells. Meng-Feng Lin (林孟鋒), Yi-Hsin Chan, Tien-Hua Chen, Hui-Chu Tsung (鍾惠菊), Hwai-Shi Wang, Po-Shiuan Hsieh, Yi-Ming Shyr, Jia-Fwu Shyu. 2009. The 24th Joint Annual Conference of Biomedical Science. Abstracts 72.

22. Increase HCN4 expression in GH3 cells stimulated with Sera of Tourette’s syndrome Patients. Chin-Bin Yeh (葉啟斌), Jia-Fwu Shyu, Tzu-Hui Chu. 2009. Taiwanese Society of Psychiatry, annual meeting abstract, I19.

23. Analysis of diabetes therapeutic potential of mesenchymal stem cells from Wharton’s Jelly in NOD mice model. Wei-Hshing Weng (翁偉雄), Joo-Shin Tan, Meng-Feng Lin (林孟鋒), Hwai-Shi Wang, Yi-Ming Shyr, Tien-Hua Chen, Yi-Hsin Chan, Jia-Fwu Shyu. 2009. The 36th Annual Military Medicine Symposium. Abstract 367.

24. Mixed symptoms of bipolar disorder related to nicotine dependence but not current smoking in young men. Yeh, C.B., Gau, S.S.F., Mao, W.C. and Shyu, J.F. 2009. European Neuropsychopharmacology. 19(S3): 449-450.

25. Analysis of the therapeutic potential of human Wharton’s jelly mesenchymal stem cells transduced by DcR3-GFP lentiviral vector in NOD mice model. Wei-Hshing Weng (翁偉雄), Joo-Shin Tan, Meng-Feng Lin (林孟鋒), Hwai-Shi Wang, Yi-Ming Shyr, Tien-Hua Chen, Yi-Hsin Chan, Jia-Fwu Shyu. 2010. The 25th Joint Annual Conference of Biomedical Science. Abstracts 106.

26. Exploring the therapeutic mechanism of human umbilical cord mesenchymal stem cells in NOD mice. Wen-Ting Chuang (莊雯婷), Joo-Shin Tan, Wei-Hshing Weng (翁偉雄), Hwai-Shi Wang, Yi-Ming Shyr, Tien-Hua Chen, Jia-Fwu Shyu. 2011. The 26th Joint Annual Conference of Biomedical Science. Abstract 155.

27. Calcitonin reduces SDCP-induced osteoclast apoptosis and increases its efficacy to treat osteoporotic rats. Wei-Yu Chen (陳韋佑), Yi-Jie Kuo, Yang-Hwei Tsuang, Jui-Sheng Sun, Chi-Hung Lin, Yi-Chian Huang, Chung Shih, and Jia-Fwu Shyu. 2011. The 26th Joint Annual Conference of Biomedical Science. Abstract 111.

28. Immunosuppressive effects of human umbilical cord stromal mesenchymal stem cells transplantation in NOD mice. Ying-Jui Lu (盧盈叡), Wen-Ting Chuang (莊雯婷), Gu-Jiun Lin, Huey-Kang Sytwu, Yi-Ming Shyr, Tien-Hua Chen, Hwai-Shi Wang, Jia-Fwu Shyu. 2012. The 27th Joint Annual Conference of Biomedical Science. Abstract 254.

29. Analysis of therapeutic potential of YC-1 for osteoporosis. Jui-Lin Chien (簡瑞林), Ni-Ko Wei (韋妮可), Tzu-Hui Chu, Chun-Jen Wang (王俊人), Mao-Hsiung Yen, Jia-Fwu Shyu. 2012. The 27th Joint Annual Conference of Biomedical Science. Abstract 257.

30. Study of the role of stomatin in cell fusion during osteoclastogenesis. Wen-Hui Chan (詹雯惠), Hsin-Yu Wu (吳歆郁), Jui-Hao Lee, Chi-Hung Lin, Jia-Fwu Shyu. 2012. The 27th Joint Annual Conference of Biomedical Science. Abstract 258.

31. Investigation of serotonin neuron activity and BDNF expression in calcitonin-treated ovariectomized hyperalgesic rats. Ni-Ko Wer (韋妮可), Jui-Lin Chien (簡瑞林), Chin-Bin Yeh, Cheng-Yi Cheng, Kuo-Hsing Ma, Jia-Fwu Shyu. 2012. The 27th Joint Annual Conference of Biomedical Science. Abstract 258.

32. Calcitonin inhibits SDCP-induced osteoclast apoptosis and increases its efficacy in a rat model of osteoporosis. Jia-Fwu Shyu, Yi-Jie Kuo, Chin-Bin Yeh, Jui-Lin Chien, Chuan-Jen Wang, Wen-Hui Chan, Ni-Ko Wei, Ying-Jui Lu, Chi-Hung Lin. 2012. Annual Meeting of American Society for Bone and Mineral Research. Abstract SU260.

33. Investigation of brain serotonin transporter activity in calcitonin-treated ovariectomized hyperalgesic rats. Jia-Fwu Shyu, Chin-Bin Yeh, Kang-Wei Chang, Yuan-Hwa Chou, Ni-Ko Wei, Tzu-Hui Chu, Jui-Lin Chien. 2012. Taiwanese Society of Psychiatry, annual meeting abstract, I12.

34. Wharton’s jelly mesenchymal stem cell ameliorate diabetes by inducing insulin-producing cell differentiation and suppressing T cell medicated autoimmunity in NOD mice. W.J. Yao, U.J. Lu, T.H. Chen, H.S. Wang, H.K. Sytwu, G.J. Lin, J.F. Shyu. 2013. The 28th Joint Annual Conference of Biomedical Science. Abstract 108.

35. The role of sclerostin in therapeutic mechanism of calcitonin in ovariectomy-induced osteoporotic rats. H.S. Ma, J.J. Wang, J.L. Jian, C.Y. Shiau, J.F. Shyu. 2013. The 28th Joint Annual Conference of Biomedical Science. Abstract 108.

36. Overexpression of stomatin induces osteoclast differentiation and decreases bone density in B6 mice. J.F. Shyu, C.H. Lin, J.H. Lee, H.Y. Wu, W.H. Chan, H.S. Ma, W.J. Yao. 2013. The 2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research. Abstract S83.

37. Usage of Wharton’s jelly-MSC for treatment of osteoporosis in IN NOD mice. J.-F. Shyu, J.-T. Cheng, T.-H. Chu, W.-Y. Chen, H.-S. Wang, T.-H. Chen. 2014. 12th Annual Meeting of International Society for Stem Cell Research. Abstract 511.