Professional Experiences

Teaching Assistant, Graduate Institute of Anatomy and Cell Biology, National Taiwan University (2005-2009)
Post doctor, Graduate Institute of Anatomy and Cell Biology, National Taiwan University (2009~2011)
Assistant Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, ROC (2011-2014)
Associated Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, ROC (2014-2018)
Professor, Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, ROC (2018-until now)

Research Interests

Investigation the mechanism of metastasis and apoptosis in the glioblastoma and bladder cancer cells.

Publications:

Publications:
1. Chang HH, Cheng YC, Tsai WC*, Chen Y*. PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through VEGFA reduction. Cancer Sci. 2020 Aug 20.
2. Changchien CY, Chen Y, Chang HH, Chang SY, Tsai WC, Tsai HC, Wang CY, Lee HS, Tsai CL*. Effect of malignant-associated pleural effusion on endothelial viability, motility, and angiogenesis in lung cancer. Cancer Sci. 2020 Jul 24.
3. Changchien CY, Sung MH, Chang HH, Tsai WC, Peng YS, Chen Y*. Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation. Chemico-Biological Interactions. 2020 Feb 8;319:108979.
4. Changchien CY, Lin YH, Cheng YC, Chang HH, Peng YS*, Chen Y*. Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades. Chemico-Biological Interactions. 2019 Mar 5;304:43-51.
5. Chang HH, Cheng YC, Tsai WC, Tsao MJ and Chen Y*. Pyr3 induces apoptosis and inhibits migration in human glioblastoma cells. Cellular Physiology and Biochemistry 2018;48(4):1694-1702.
6. Cheng YC, Tsao MJ, Chiu CY, Kan PC, Chen Y*. Magnolol inhibits human glioblastoma cell migration by regulating N-cadherin. J Neuropathol Exp Neurol. 2018 Jun 1;77(6):426-436.
7. Cheng YC, Tsai WC, Sung YC, Chang HH, Chen Y*. Interference with PSMB4 Expression Exerts an Anti-Tumor Effect by Decreasing the Invasion and Proliferation of Human Glioblastoma Cells. Cellular Physiology and Biochemistry 2018 Feb 45:819-831.
8. Fann LY, Chen Y, Chu DC, Weng SJ, Chu HC, Wu Alexander T.H., Lee JF, Ahmed Atef Ahmed Ali, Chen TC, Huang HS*, Ma KH*. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget 2017 Dec.
9. Hueng DY, Hsieh CH, Cheng YC, Tsai WC, Chen Y*. Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation. J Nutr Biochem. 2017 Mar 41:109-116.
10. Feng SW, Chen Y, Tsai WC, Chiou Clair HY, Wu ST, Huang LC, Lin C, Hsieh CC, Yang YJ, Hueng DY*. Overexpression of TELO2 decreases survival in human highgrade gliomas. Oncotarget 2016 Jul 19;7(29):46056-46066.
11. Cheng YC, Hueng DY, Huang HY , Chen JY and Chen Y*. Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas. Oncotarget 2016
12. Cheng YC, Ding YM, Hueng DY, Chen JY and Chen Y*. Caffeine Suppresses the Progression of Human Glioblastoma via Cathepsin B and MAPK Signaling Pathway. The Journal of Nutritional Biochemistry. 2016
13. Wu YC, Jhao YT, Cheng YC, Chen Y*. 15-Deoxy-Delta-12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction. Oncology Letters. 2016
14. Lin CY, Hsu YJ, Hsu SC, Chen Y, Lee HS, Lin SH, Huang SM, Tsai CS, Shih CC. CB1 cannabinoid receptor antagonist attenuates left ventricular hypertrophy and Akt-mediated cardiac fibrosis in experimental uremia. J Mol Cell Cardiol. 2015 Jun 18;85:249-261.
15. Yang SH, Wang SM, Syu JP, Chen Y, Wang SD, Peng YS, Kuo F and Kung HN. Andrographolide induces apoptosis of C6 glioma cells via the ERK-p53-caspase 7-PARP pathway. BioMed Research International. 2014
16. Chen Y*, Chou WC, Ding YM, Wu YC. Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway. Cellular Physiology and Biochemistry. 2014 Jun 33:1888-1898. *first and corresponding author
17. Chen Y*, Yang SH, Hueng DY, Syu JP, Liao CC, Wu YC. Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chemico-Biological Interactions. 2014 Jun 216:17–25. *first and corresponding author
18. Tsai WC, Chen Y, Huang LC, Lee HS, Ma HI, Huang SM, Sytwu HK, Hueng DY*. EMMPRIN expression positively correlates with WHO grades of astrocytomas and meningiomas. J Neurooncol. 2013 Sep;114(3):281-90.
19. Peng YS, Lin YT, Wang SD, Hung KY, Chen Y* and Wang SM*. p-Cresol induces disruption of cardiomyocyte adherens junctions. Toxicology. 2013. Apr 5;306:176-84. *Co-corresponding author
20. Chen Y*, Chen YC. Oleic acid induces adherens junction disassembly in rat neonatal cardiomyocytes through mechanisms involving Fyn kinase and casein kinase 1. Journal of Medical Science. 2013. Feb 33(1):11-19.
21. Peng YS, Ding HC, Lin YT, Syu JP, Chen Y*, Wang SM*. Uremic Toxin p-cresol Induces Disassembly of Gap Junctions of Cardiomyocytes. Toxicology. 2012. Dec 8;302(1):11-7. *Co-corresponding author
22. Yang SH, Liao CC, Chen Y, Syu JP, Jeng CJ, Wang SM. Daidzein Induces Neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science. 2012. Aug 29;19(1):80.
23. Peng YS, Lin YT, Chen Y, Hung KY, Wang SM*. Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism. J Cell Biochem. 2012. Mar 113(3):1034-43.
24. Chen Y*, Kung HN*, Chen CH, Huang SH, Chen KH, Wang SM*. Acidic extracellular pH induces p120-catenin-mediated disruption of adherens junctions via the Src kinase-PKCδ pathway. FEBS Lett. 2011. *Co-first author
25. Yang SH, Jeng CJ, Chen CH, Chen Y, Chen YC, Wang SM. Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons. J Sci Food Agr 2011 Mar 15;91(4):694-702.
26. Chen Y, Chen YC, Lin YT, Huang SH, Wang SM. Cordycepin induces apoptosis of CGTH-W2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway. J Agric Food Chem. 2010 Nov 24;58(22):11645-52.
27. Chen YC, Chen Y, Huang SH, Wang SM. Protein kinase Cmu mediates adenosine-stimulated steroidogenesis in primary rat adrenal cells. FEBS Lett. 2010 Nov 5;584(21):4442-8.
28. Lin CJ, Lin CY, Chen Y, Huang SH, Wang SM. Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex. J Cell Biochem. 2010 Mar 11;110:428-437.
29. Chen Y, Chen CH, Tung PY, Huang SH, Wang SM. An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin. J Cell Biochem. 2009 Nov 1;108(4):851-9.
30. Chen KH, Tung PY, Wu JC, Chen Y, Chen PC, Huang SH, Wang SM. An acidic extracellular pH induces Src kinase-dependent loss of beta-catenin from the adherens junction. Cancer Lett. 2008 Aug 18;267(1):37-48.
31. Yang SH, Chen YJ, Tung PY, Lai WL, Chen Y, Jeng CJ, Wang SM. Anti-Thy-1 antibody-induced neurite outgrowth in cultured dorsal root ganglionic neurons is mediated by the c-Src-MEK signaling pathway. J Cell Biochem. 2008 Jan 1;103(1):67-77
32. Huang SH, Chen Y, Tung PY, Wu JC, Chen KH, Wu JM, Wang SM. Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells. J Cell Biochem. 2007 Jul 1;101(4):1011-22.
33. Chen Y, Wang SM, Wu JC, Huang SH. Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line. J Cell Biochem. 2006 Jul 1;98(4):1021-35.
34. Chen YC, Chang MF, Chen Y, Wang SM. Signaling pathways of magnolol-induced adrenal steroidogensis. FEBS Lett. 2005 579 (20): 4337-4343.
◎Conferences and Invited Speakers
1. Cheng YC, Sung YC, Chang HH, Chen Y. Knockdown of PSMB4 exert an anti-tumor effect through reducing the proliferation and invasion in human glioblastomas. 40th annual meeting of the Molecular Biology Society of Japan
2. Cheng YC, Ding YM, Hueng DY, Chen Y. Caffeine Suppresses the Progression of Human Glioblastoma via Down-regulation of Cathepsin B and MAPK Signaling Pathway. 38th annual meeting of the Molecular Biology Society of Japan
3. Chen Y, Yang SH, Lin YT, Wang SM. Cordycepin caused C6 glioma cells apoptosis through caspase 7 activation in a A2AR dependent manner. 34th annual meeting of the Molecular Biology Society of Japan
4. Peng YS, Sung MH, Syu JP, Chen Y and Wang SM. Indoxyl sulfate induces JNK-mediated downregulation of connexin 43 in neonatal cultured cardiomyocytes. 14th International Congress of Histochemistry and Cytochemistry

Awards

1. "Outstanding Graduate Writing Award" masterpiece of the National Taiwan University College of Medicine (2007)
2. Poster masterpiece of natural products Application Development Seminar (2010)

Laboratory Description

We studies the mechanism of migration and invasion in glioblastoma cells and bladder cancer cells by natural substances. We found the compound in daily drinks – caffeine can inhibit migration and invasion of human glioma cells. In addition, we also found that cordycepin suppresses human glioblastoma migration and invasion. Currently, we begin to investigate the role of proteasomes in glioblastoma cells in vitro and in vivo. Moreover, the treatment of magnolol in bladder carcinoma is also an ongoing project. Welcome to join us to study the migration and invasion in glioblastoma and bladder cancer cells.