Position

Associate Professor

Education

Ph.D., Ph.D., Institute of Biochemistry and Molecular Biology, National Yang-Ming University, ROC

M.S., M.S., Department of Life Science, National Tsing Hua University, ROC

B.S., Department of Microbiology, Soochow University., ROC

Email

blue2010@mail.ndmctsgh.edu.tw

Research Interests

1.Study the regulation mechanisms of endocrine disrupting chemicals (EDCs)

2.Investigate the post-traumatic stress disorder (PTSD) animals on endocrine systems

Publications

1. Hsin-Chieh Lan*, Jyun-Hong Lin, Chang-Hao Chen, Po-Wei Chu, and Chia-Pi Cheng (2018, Jul).

Estradiol Level of Male Rat is Correlated with Depression and Anxiety after Traumatic Stress. Journal of Medical Sciences, 38(4):176-84. MAB-105-060. 本人為第一作者、通訊作者



2. Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Kai-Yu Wu, GwoJang Wu, Hsin-Chieh

Lan* (2018,Feb). Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells. Biology of Reproduction, 1;98(2):250-258.

(IF: 3.184, SCI, 17.2% in Reproductive Biology). MOST 104-2320-B-016-015. 本人為通訊作者



3. Hsin-Chieh Lan*, Kai-Yu Wu, I-Wen Lin, Zhi-Jie Yang, Ai-An Chang, MengChun Hu (2017, Oct). Bisphenol A disrupts steroidogenesis and induces a sex hormone imbalance through c-Jun phosphorylation in Leydig cells. Chemosphere, 2017 Oct;185:237-246. (IF: 4.427, 14.5% in Environmental Sciences, SCI ). MOST 102-2320-B-016-001-MY2. 本人為第一作者、通訊作者



4. Hsin-Chieh Lan*, I-Wen Lin, Zhi-Jie Yang and Jyun-Hong Lin (2015, Nov). Low-dose Bisphenol A Activates Cyp11a1 Gene Expression and Corticosterone Secretion in Adrenal Gland via the JNK Signaling Pathway. Toxicological Sciences, 148 (1), 26-34. (IF: 4.181, SCI, 14.9% in Toxicology).

NSC 102-2320-B-016-001-MY2. 本人為第一作者、通訊作者



5. Hsin-Chieh Lan, Chih-Feng Wu, Hsiu-Ming Shih, and Bon-chu Chung* (2012, Feb). Death-Associated Protein 6 (Daxx) Mediates cAMP-Dependent Stimulation of Cyp11a1 transcription. Journal of Biological Chemistry, 287, 5910-5916. (IF: 4.011, SCI, 25.6% in Biochemistry & Molecular Biology). 本人為第一作者



6. Ing-Cherng Guo, Meng-Chun Shih, Hsin-Chieh Lan, Nai-Chi Hsu, Meng-Chun Hu, Bon-chu Chung* (2007, Jul). Transcriptional regulation of human CYP11A1 in gonads and adrenals. Journal of Biomedical Science, 14(4), 509-515. (IF: 3.466, SCI, 34.5% in Medicine, Research & Experimental).



7. Hsin-Chieh Lan, Hua-Jung Li, Guang Lin, Pao-Yen Lai, Bon-chu Chung* (2007, Mar). Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Mol Cell Biol., 27(6):2027-2036. (IF: 3.813, SCI, 29% in Biochemistry & Molecular Biology). 本人為第一作者

Laboratory Description

There is increasing evidence that various chemicals introduced into the living environment artificially. These chemicals are always abusive because of elimination their side effects in human or other organisms. The endocrine disrupting chemicals (EDCs, also called environmental hormones) cause the most severe damage due to the uneasy digestion property and accumulation in bodies for long time. Previous studies reveal that EDCs injure endocrine and reproduction system, such as sexual reverse in fish, decline of ovulation in birds, and abnormal spermatogenesis in mammalians. However, many researches only study on the physiological observation and analysis.

In order to understand the reaction mechanism of EDCs, my lab focuses on the regulation of steroidogenesis pathway. The target genes of our study are CYP11A1 and CYP19 that encode P450scc and aromatase enzymes those convert cholesterol to glucocorticoid, mineralocorticoid and sex steroids. The human choriocarcinoma JEG3 cells and mouse Leydig tumor MA-10 cells are two major models for the study to represent the EDCs damage in mammalian, like abortion or sperm abnormality. The results of our research can explain the exactly mechanisms of EDCs and may provide some insights to protect from these damage.