Position

Associate Professor

Education

Ph.D., Graduate Institute of Anatomy and Cell Biology, National Taiwan University, ROC

M.S., Graduate Institute of Anatomy and Cell Biology, National Taiwan University, ROC

B.S., Department of Life Sciences, National Cheng Kung University, ROC

Email

anatoman2001@yahoo.com.tw

Professional Experiences

1. Assistant Professor, Department of Anatomy, Chung Shan Medical University, ROC (2007~2012)

2. Assistant Professor, Department of Biology and Anatomy, National Defense Medical Center (2012~present)

Research Interests

1.Investigation of the mechanism of the autophagy of MDMA –induced neurotoxicity

2.Neuroprotective effects of mesenchymal stem cells.

Publications

1. Li IH, Ma KH, Kao TJ, Lin YY, Weng SJ, Yen TY, Chen LC, Huang YS*. Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity. Neurotoxicology 2015; 52:114-126. IF=3.379, (R/C=20/88，Toxicology)

2. Shih JH, Ma KH, Chen CF, Cheng CY, Pao LH, Weng SJ, Huang YS, Shiue CY, Yeh MK, Li IH. Evaluation of brain SERT occupancy by resveratrol against MDMA-induced neurobiological and behavioral changes in rats: A 4-[18F]-ADAM/small-animal PET study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2015. IF=4.369, 27/192 (14%) in Clinical neurology

3. Weng SJ, Li IH, Huang YS, Chueh SH, Chou TK, Huang SY, Shiue CY, Cheng CY, Ma KH. KA-bridged transplantation of mesencephalic tissue and olfactory ensheathing cells in a Parkinsonian rat model. Journal of tissue engineering and regenerative medicine 2015. IF=5.199, 5/76 (6.57%) in Engineering, Biomedical.

4. Chiu CH, Li IH, Weng SJ, Huang YS, Wu SC, Chou TK, Huang WS, Liao MH, Shiue CY, Cheng CY, Ma KH. PET imaging of serotonin transporters with 4-[18F]-ADAM in a Parkinsonian rat model with porcine neural xenografts. Cell transplantation 2015. IF=3.127 (34.14%) in Medicine, Research & Experimental

5. Chiu CH, Siow TY, Weng SJ, Hsu YH, Huang YS, Chang KW, Cheng CY, Ma KH. Effect of MDMA-Induced Axotomy on the Dorsal Raphe Forebrain Tract in Rats: An In Vivo Manganese-Enhanced Magnetic Resonance Imaging Study. PloS one 2015; 10:e0138431. IF=3.234, 9/57 (15.7%) in MULTIDISCIPLINARY SCIENCES

6. Chen YJ, Huang YS, Chen JT, Chen YH, Tai MC, Chen CL, and Liang CM. Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury. Investigative ophthalmology & visual science. 2015;56:1506-16. IF=3.661, 7/57 (12.2%) in OPHTHALMOLOGY.

7. Li IH, Ma KH, Weng SJ, Huang SS, Liang CM, Huang YS*. Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced neurotoxicity in cultured cortical neurons. PloS one. 2014;9(12):e116565. IF=3.234, 9/57 (15.7%) in MULTIDISCIPLINARY SCIENCES.

8. Liang CM, Weng SJ, Tsai TH, Li IH, Lu PH, Ma KH, Tai MC, Chen JT, Cheng CY, Huang YS*. Neurotrophic and neuroprotective potential of human limbus-derived mesenchymal stromal cells. Cytotherapy. 2014 Jul 2. 16: 1371-1383. IF=3.293, 42/163 (25.76%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY.

9. Huang YS, Li IH, Chueh SH, Hueng DY, Tai MC, Liang CM, Lien SB, Sytwu HK, Ma KH. Mesenchymal stem cells from rat olfactory bulbs can differentiate into cells with cardiomyocyte characteristics. Journal of tissue engineering and regenerative medicine. 2013 Feb 4. IF=5.199, 5/76 (6.57%) in Engineering, Biomedical.

10. Huang SS, Cheng H, Tang CM, Nien MW, Huang YS, Lee IH, Yin JH, Kuo TB, Yang CC, Tsai SK, Yang DI. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental neurology. 2013 Sep;247:680-8. IF=4.696; 47/252 (18.65%) in NEUROSCIENCE.

11. Huang YS, Cheng CY, Chueh SH, Hueng DY, Huang YF, Chu CM, Wu ST, Tai MC, Liang CM, Liao MH, Chen CC, Shen LH, Ma KH. Involvement of SHP2 in focal adhesion, migration and differentiation of neural stem cells. Brain & development. 2012 Sep;34(8):674-84. IF=1.880, 119/192 (61.97%) in CLINICAL NEUROLOGY.

Laboratory Description

Our laboratory is interested in the investigation of the mechanism of the autophagy of MDMA –induced neurotoxicity and neuroprotective effects of mesenchymal stem cells.
Autophagy is a dynamic cellular pathway involved in the turnover of organelles and damaged proteins through lysosomal degradation, which plays a critical role in cell growth, differentiation and homeostasis. Moreover, 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug, and has also been shown to cause serotonergic and cortical neuron toxicity in the brain. While the role of autophagy in MDMA-induced neurotoxicity has not been investigated. Currently, We have showed the connection of MDMA- induced neurotoxicity and autophagy, and furthermore revealed the different effect of neuroprotective drug in the signaling pathway of autophagy.
Also, we have focus on the different role of mesenchymal stem cells. One of our study is working on the secreted neurotrophic factor from limbal mesenchymal cells and tested the effect on the wound rat brain. The other study is about the differentiation of mesenchymal stem cells extracted from rat olfactory bulbs.