Position

Assistant Professor

Education

Ph.D., University of Taiwan ROC

M.S., University of Taiwan ROC

B.S., University of Taiwan ROC

Professional Experiences

Assistant Professor, Dep. of Biology and Anatomy, NDMC (2001~)

Director, Dep. of Research, We Gene Technologies (2000~2001)

Adjunct Assistant Professor, Tzu Chi University (1999-2000)

Adjunct Assistant Professor, Tzu Chi college of Technology (1998-1999)

Post doctor, Tzu Chi University (1997~2000)

Instructor, Dep. of Biology and Anatomy, NDMC (1983~1993)

Research Interests

Regulation of epidermal cell differentiation

Email

jychen01@mail.ndmctsgh.edu.tw

Research Activities&Accomplishments

1. Mechanisms of melanosomes transfer from melanocytes to keratinocytes in cell co-cultured system
2. Mechanisms of p53 and p63 regulate K14 expression at epidermal cell differentiation.

Honors and Awards

Medical Research Award, Third Prize of Poster for graduate student as advisor at 35th Annual Military Medicine Symposium, 2008

Medical Research Award, Secondary Prize of Poster for graduate student as advisor at 36th Annual Military Medicine Symposium, 2009

Publications

1. Bi-He Cai, Chung-Faye Chao, Hwang-Chi Lin, Hua-Ying Huang, Reiji Kannagi and Jang-Yi Chen* (2016)A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements. J. Biochem. 1-10 doi:10.1093/jb/mvw005. ( I F=2.582；R/C= 154/290 )

2. Gnu-Jiun Lin, Shu-Sheng Kao Chen, Shing-Hwa Huang, I-Hsun Li, Li-Chen Yen, Jang-Yi Chen, Huey-Kang Sytwu, Yuan-Wu Chen. (2015) Valproic acid exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo. J Med Sci 35(1):28-36

3. Bi-He Cai, Pei-Ching Hsu, I-Lun Hsin, Chung-Faye Chao, Mei-Hua Lu, Hwang-Chi Lin, Shih-Hwa Chiou, Pao-Luh Tao, and Jang-Yi Chen*. (2012) p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. PLoS ONE 7(7): e41742. doi:10.1371/journal.pone.0041742. ( I F=3.23；R/C=9/57)

4. Cai BH, Chao CF, Lu MH, Lin HC, and Chen JY *. (2012) A half-site of the p53 binding site on the keratin 14 promoter is specifically activated by p63. J Biochem 152: 99-110 ( I F=2.582；R/C= 154/290 )

5. Cai BH, Chen JY, Lu MH, Chang LT, Lin HC, Chang YM, Chao CF*. Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53. Nucleic Acids Res. 2009;37(6):1984-1990. ( I F=9.112；R/C= 20/290 )

6. Lin HC, Shieh BH, Lu MH, Chen JY, Chang LT, Chao CF*. A method for quantifying melanosome transfer efficacy from melanocytes to keratinocytes in vitro. Pigment Cell Melanoma Res. 2008;21; 559–564. ( I F=5.509；R/C= 2/58 ).

7. Lu MH*, Chao CF, Tsai SH, Chen JY, and Chang LT Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats. Clin Exp Hypertens 2006; 28:463–474. SCI

8. Chang, W.C., Chen, J.Y., Chang, T., Liu, M.Y., Payne, W.J., LeGall, J. and Chang, W.C. The C-terminal Segment is Essential for Maintaining Quaternary and Structure the Enzyme Activity of the Nitric Oxide Forming Nitrite Reductase from Achromobacter cycloclastes. Biochem. Biophys. Res. Commun. 250:782-785. 1998. SCI

9. Chen, J.Y., Chang, W.C., Chang, T., Chang, W.C., Liu, M.Y., Payne, W.J. and LeGall, J. Cloning, Characterization and Expression of the Nitric Oxide-Generating Nitrite Reductase and of the Blue Copper Protein Genes of Achromobacter cycloclastes. Biochem. Biophys. Res. Commun. 219:423-428. 1996. SCI

10. Chen, J.Y., Chang, W.C. and Chao, C.F. The Induction and Characterization of Antiserum against Human Placenta 17--Hydroxysteroid Dehydrogenase. Proc. Natl. Sci. Counc. (B) ROC. 17:106-115. 1993.